Researchers from Xi'an Jiaotong-Liverpool University, Stanford University, Shanghai Jiao Tong University and the University of Chinese Academy of Sciences investigated compounds called plasmalogens, which are naturally occurring fats found in high levels in sea squirts.
Sea squirts are marine animals eaten in parts of Asia, including Korea and Japan.
Plasmalogens are important components of cell membranes and are particularly abundant in the brain, heart and immune cells. Their levels naturally decline with age.
In the study, researchers added plasmalogens to the diets of aging mice and examined changes in their memory, brain health and physical appearance.
The results showed that the treated mice performed significantly better in tests of learning and memory than older mice that did not receive the supplements.
Researchers used the Morris water maze, a common test in which mice must learn to locate a hidden platform.
After five days of training, mice receiving plasmalogens reached the platform faster, performing more like younger animals.
When scientists examined their brains, they found that the treated mice had more synapses, the connections that allow nerve cells to communicate. These connections also appeared to be in better condition.
The researchers also found substantially lower levels of inflammation in the brains of mice receiving plasmalogens.
Chronic inflammation in the aging brain can damage nerve cells and interfere with communication between brain cells, potentially contributing to cognitive decline.
Another surprising finding involved the mice's appearance. According to the researchers, older mice receiving plasmalogens developed new hair that was thicker, darker and glossier than that of untreated mice.
Scientists believe plasmalogens may work through several mechanisms.
They may encourage the development of neurons and synapses, improve the flexibility of cell membranes and potentially influence the gut-brain connection.
However, researchers stress that the findings do not yet prove that plasmalogens can reverse aging in humans.
The study was conducted in mice, and further research is needed to determine whether similar effects occur in people, what dosage might be effective and whether long-term supplementation is safe.
Source : https://new.igihe.com/english/seafood-compound-reverses-signs-of-aging-in-mice-study-finds/
